Standard

Aspartate aminotransferase to alanine aminotransferase ratio

near ZNF250 · rs71522403

Where this position leads

Condition: Gout

rs71522403 Condition: Gout Gout Condition rs71522403 rs71522403 near ZNF250

What the study found

Who was studied 341,165 European ancestry individuals, 5,981 African ancestry individuals, 7,309 South Asian ancestry individuals.

The effect Each copy of the G allele shifted the measure 0.0237 higher (95% confidence interval 0.017-0.03); p = 6 × 10−12.

Where it sits Chromosome 8, band 8q24.3 — between genes, 8.8 kb from ZNF250.

What each result means

C/C No copy of the version the research linked to Aspartate aminotransferase to alanine aminotransferase ratio. This is the starting point the study compared everyone against.
C/G One copy of the version the research linked to Aspartate aminotransferase to alanine aminotransferase ratio. That is a smaller link than two copies.
G/G Two copies of the version the research linked to Aspartate aminotransferase to alanine aminotransferase ratio. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs71522403

What is rs71522403?

rs71522403 is a single position in the genome, in or near the near ZNF250 gene. Published research associates it with aspartate aminotransferase to alanine aminotransferase ratio. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs71522403 linked to?

On MyGeneLog this position is linked to Gout. The research behind each link, and its sources, are set out on that condition page.

Does having rs71522403 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs71522403 come from?

GWAS Catalog, Nature genetics 2021, PMID:33462484. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Aspartate aminotransferase to alanine aminotransferase ratio (rs71522403). MyGeneLog™. https://www.mygenelog.com/variants/rs71522403

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