Sensitive

Rheumatoid arthritis

ARID5B · rs71508903

Where this position leads

What the study found

Who was studied up to 14,361 European ancestry cases, up to 42,923 European ancestry controls, up to 4,873 East Asian ancestry cases, up to 17,642 East Asian ancestry controls; replicated in up to 3,775 European ancestry cases, up to 5,801 European ancestry controls, up to 6,871 East Asian ancestry cases, up to 6,392 East Asian ancestry controls.

The effect Each copy of the T allele carried 1.18 times the odds of Rheumatoid arthritis (95% confidence interval 1.12-1.25); p = 1 × 10⁻⁸.

How common The T allele had a frequency of about 24% in the people studied.

Where it sits Chromosome 10, band 10q21.2 — in an intron of ARID5B.

What each result means

C/C No copy of the version the research linked to Rheumatoid arthritis. This is the starting point the study compared everyone against.

C/T One copy of the version the research linked to Rheumatoid arthritis. That is a smaller link than two copies.

T/T Two copies of the version the research linked to Rheumatoid arthritis. That is the strongest link of the three results. A link in a study is not a diagnosis.

Source

Genetics of rheumatoid arthritis contributes to biology and drug discovery

Okada Y, Wu D, Trynka G, Raj T, Terao C, Ikari K, Kochi Y, Ohmura K, Suzuki A, Yoshida S, Graham RR, Manoharan A

and 83 more — show all

Ortmann W, Bhangale T, Denny JC, Carroll RJ, Eyler AE, Greenberg JD, Kremer JM, Pappas DA, Jiang L, Yin J, Ye L, Su DF, Yang J, Xie G, Keystone E, Westra HJ, Esko T, Metspalu A, Zhou X, Gupta N, Mirel D, Stahl EA, Diogo D, Cui J, Liao K, Guo MH, Myouzen K, Kawaguchi T, Coenen MJ, van Riel PL, van de Laar MA, Guchelaar HJ, Huizinga TW, Dieudé P, Mariette X, Bridges SL Jr, Zhernakova A, Toes RE, Tak PP, Miceli-Richard C, Bang SY, Lee HS, Martin J, Gonzalez-Gay MA, Rodriguez-Rodriguez L, Rantapää-Dahlqvist S, Arlestig L, Choi HK, Kamatani Y, Galan P, Lathrop M, Eyre S, Bowes J, Barton A, de Vries N, Moreland LW, Criswell LA, Karlson EW, Taniguchi A, Yamada R, Kubo M, Liu JS, Bae SC, Worthington J, Padyukov L, Klareskog L, Gregersen PK, Raychaudhuri S, Stranger BE, De Jager PL, Franke L, Visscher PM, Brown MA, Yamanaka H, Mimori T, Takahashi A, Xu H, Behrens TW, Siminovitch KA, Momohara S, Matsuda F, Yamamoto K, Plenge RM

RACI consortium · GARNET consortium

Nature · 2014 · PMID 24390342 · open access

Questions about rs71508903

What is rs71508903?

rs71508903 is a single position in the genome, in or near the ARID5B gene. Published research associates it with rheumatoid arthritis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs71508903 linked to?

On MyGeneLog this position is linked to Rheumatoid Arthritis. The research behind each link, and its sources, are set out on that condition page.

Does having rs71508903 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs71508903 come from?

GWAS Catalog, Nature 2013, PMID:24390342. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Rheumatoid arthritis (rs71508903). MyGeneLog™. https://www.mygenelog.com/variants/rs71508903

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