Standard
Left ventricular end diastolic volume (indexed to body surface area)
near MYH7 · rs7143356
Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 36,083 European or unknown ancestry individuals.
The effect
Each copy of the T allele shifted the measure 0.603 higher (95% confidence interval 0.42-0.79); p = 2 × 10−10.
How common The T allele had a frequency of about 62% in the people studied.
Where it sits Chromosome 14, band 14q11.2 — between genes, 0.9 kb from MYH7.
What each result means
C/C
Published research associates this genotype with typical/baseline likelihood of Left ventricular end diastolic volume (indexed to body surface area) — no copies of the reported risk allele.
C/T
Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Left ventricular end diastolic volume (indexed to body surface area).
T/T
Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Left ventricular end diastolic volume (indexed to body surface area) compared to the general population.
Source
Large-scale genome-wide association analyses identify novel genetic loci and mechanisms in hypertrophic cardiomyopathy
Tadros R,
Zheng SL,
Grace C,
Jordà P,
Francis C,
West DM,
Jurgens SJ,
Thomson KL,
Harper AR,
Ormondroyd E,
Xu X,
Theotokis PI
and 50 more — show all
Buchan RJ,
McGurk KA,
Mazzarotto F,
Boschi B,
Pelo E,
Lee M,
Noseda M,
Varnava A,
Vermeer AMC,
Walsh R,
Amin AS,
van Slegtenhorst MA,
Roslin NM,
Strug LJ,
Salvi E,
Lanzani C,
de Marvao A,
Roberts JD,
Tremblay-Gravel M,
Giraldeau G,
Cadrin-Tourigny J,
L'Allier PL,
Garceau P,
Talajic M,
Gagliano Taliun SA,
Pinto YM,
Rakowski H,
Pantazis A,
Bai W,
Baksi J,
Halliday BP,
Prasad SK,
Barton PJR,
O'Regan DP,
Cook SA,
de Boer RA,
Christiaans I,
Michels M,
Kramer CM,
Ho CY,
Neubauer S,
Matthews PM,
Wilde AAM,
Tardif JC,
Olivotto I,
Adler A,
Goel A,
Ware JS,
Bezzina CR,
Watkins H
Nature genetics · 2025 · PMID 39966646 · open access
Questions about rs7143356
What is rs7143356?
rs7143356 is a single position in the genome, in or near the near MYH7 gene. Published research associates it with left ventricular end diastolic volume (indexed to body surface area). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs7143356 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs7143356 come from?
GWAS Catalog, Nature genetics 2025, PMID:39966646. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Left ventricular end diastolic volume (indexed to body surface area) (rs7143356). MyGeneLog™. https://www.mygenelog.com/variants/rs7143356
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