1 4222127223120Reads by AI crawlersClaude2ChatGPT2Google · Gemini1Perplexity2Meta AI7Microsoft · Copilot2Amazon2Apple3China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others20Total42Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Who was studied 1,268 European, South Asian, East Asian, African American/Afro-Caribbean, Hispanic and other ancestry cases; replicated in 1,267 European, South Asian, East Asian, African American/Afro-Caribbean, Hispanic and other ancestry cases.
The effect
Each copy of the C allele carried 3.61 times the odds of Acute lymphoblastic leukemia (childhood) (95% confidence interval 2.34-5.57); p = 7 × 10−9.
How common The C allele had a frequency of about 1% in the people studied.
Where it sits Chromosome 14, band 14q22.1 — in an intron of PYGL.
What each result means
C/CTwo copies of the version the research linked to Acute lymphoblastic leukemia (childhood). That is the strongest link of the three results. A link in a study is not a diagnosis.
C/TOne copy of the version the research linked to Acute lymphoblastic leukemia (childhood). That is a smaller link than two copies.
T/TNo copy of the version the research linked to Acute lymphoblastic leukemia (childhood). This is the starting point the study compared everyone against.
rs7142143 is a single position in the genome, in or near the PYGL gene. Published research associates it with acute lymphoblastic leukemia (childhood). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs7142143 linked to?
On MyGeneLog this position is linked to Acute Lymphoblastic Leukemia. The research behind each link, and its sources, are set out on that condition page.
Does having rs7142143 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs7142143 come from?
GWAS Catalog, Blood 2012, PMID:23007406. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
1 4222127223120Reads by AI crawlersClaude2ChatGPT2Google · Gemini1Perplexity2Meta AI7Microsoft · Copilot2Amazon2Apple3China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others20Total42Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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