Standard
Acute lymphoblastic leukemia (childhood)
PYGL · rs7142143
Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What each result means
C/C
Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Acute lymphoblastic leukemia (childhood) compared to the general population. (GWAS Catalog, Blood 2012, PMID:23007406)
C/T
Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Acute lymphoblastic leukemia (childhood). (GWAS Catalog, Blood 2012, PMID:23007406)
T/T
Published research associates this genotype with typical/baseline likelihood of Acute lymphoblastic leukemia (childhood) — no copies of the reported risk allele. (GWAS Catalog, Blood 2012, PMID:23007406)
Source
Genome-wide association study identifies germline polymorphisms associated with relapse of childhood acute lymphoblastic leukemia
Yang JJ,
Cheng C,
Devidas M,
Cao X,
Campana D,
Yang W,
Fan Y,
Neale G,
Cox N,
Scheet P,
Borowitz MJ,
Winick NJ
and 11 more — show all
Martin PL,
Bowman WP,
Camitta B,
Reaman GH,
Carroll WL,
Willman CL,
Hunger SP,
Evans WE,
Pui CH,
Loh M,
Relling MV
Blood · 2012 · PMID 23007406
Questions about rs7142143
What is rs7142143?
rs7142143 is a single position in the genome, in or near the PYGL gene. Published research associates it with acute lymphoblastic leukemia (childhood). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs7142143 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs7142143 come from?
GWAS Catalog, Blood 2012, PMID:23007406. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
← See all variants