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Who was studied 4,442 European ancestry cases, 1,104,335 European ancestry controls; replicated in 725 cases, 164,346 controls.
The effect
Each copy of the T allele carried 1.14 times the odds of Chronic lymphocytic leukemia (95% confidence interval 1.09-1.19); p = 2 × 10−8.
How common The T allele had a frequency of about 26% in the people studied.
Where it sits Chromosome 12, band 12q24.22 — in an intron of MAP1LC3B2.
What each result means
G/GNo copy of the version the research linked to Chronic lymphocytic leukemia. This is the starting point the study compared everyone against.
G/TOne copy of the version the research linked to Chronic lymphocytic leukemia. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Chronic lymphocytic leukemia. That is the strongest link of the three results. A link in a study is not a diagnosis.
Blood cancer journal · 2025 · PMID 40883272 · open access
Questions about rs7133288
What is rs7133288?
rs7133288 is a single position in the genome, in or near the MAP1LC3B2 gene. Published research associates it with chronic lymphocytic leukemia. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs7133288 linked to?
On MyGeneLog this position is linked to Chronic Lymphocytic Leukaemia. The research behind each link, and its sources, are set out on that condition page.
Does having rs7133288 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs7133288 come from?
GWAS Catalog, Blood cancer journal 2025, PMID:40883272. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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