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COVID-19 (critical illness vs population)

near LZTFL1 · rs71325088

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 2,804 European ancestry cases, 2,415 European, South Asian and Hispanic or Latin American ancestry cases, 687,911 European ancestry controls, 477,741 European, South Asian and Hispanic or Latin American ancestry controls.

The effect Each copy of the C allele carried 1.90 times the odds of COVID-19 (critical illness vs population) (95% confidence interval 1.73-2.0); p = 3 × 10−54.

Where it sits Chromosome 3, band 3p21.31 — between genes, 1.9 kb from LZTFL1.

What each result means

C/C Two copies of the version the research linked to COVID-19 (critical illness vs population). That is the strongest link of the three results. A link in a study is not a diagnosis.
C/T One copy of the version the research linked to COVID-19 (critical illness vs population). That is a smaller link than two copies.
T/T No copy of the version the research linked to COVID-19 (critical illness vs population). This is the starting point the study compared everyone against.
Source
Genetic mechanisms of critical illness in COVID-19
Pairo-Castineira E, Clohisey S, Klaric L, Bretherick AD, Rawlik K, Pasko D, Walker S, Parkinson N, Fourman MH, Russell CD, Furniss J, Richmond A
and 54 more — show all
Gountouna E, Wrobel N, Harrison D, Wang B, Wu Y, Meynert A, Griffiths F, Oosthuyzen W, Kousathanas A, Moutsianas L, Yang Z, Zhai R, Zheng C, Grimes G, Beale R, Millar J, Shih B, Keating S, Zechner M, Haley C, Porteous DJ, Hayward C, Yang J, Knight J, Summers C, Shankar-Hari M, Klenerman P, Turtle L, Ho A, Moore SC, Hinds C, Horby P, Nichol A, Maslove D, Ling L, McAuley D, Montgomery H, Walsh T, Pereira AC, Renieri A, Shen X, Ponting CP, Fawkes A, Tenesa A, Caulfield M, Scott R, Rowan K, Murphy L, Openshaw PJM, Semple MG, Law A, Vitart V, Wilson JF, Baillie JK
GenOMICC Investigators · ISARIC4C Investigators · COVID-19 Human Genetics Initiative · 23andMe Investigators · BRACOVID Investigators · Gen-COVID Investigators
Nature · 2021 · PMID 33307546

Questions about rs71325088

What is rs71325088?

rs71325088 is a single position in the genome, in or near the near LZTFL1 gene. Published research associates it with covid-19 (critical illness vs population). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs71325088 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs71325088 come from?

GWAS Catalog, Nature 2021, PMID:33307546. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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COVID-19 (critical illness vs population) (rs71325088). MyGeneLog™. https://www.mygenelog.com/variants/rs71325088

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