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Who was studied 180,129 European ancestry cases, 180,709 European ancestry controls.
The effect
Each copy of the C allele carried 1.04 times the odds of Allergic disease (asthma, hay fever or eczema) (95% confidence interval 1.03-1.06); p = 7 × 10−15.
How common The C allele had a frequency of about 69% in the people studied.
Where it sits Chromosome 11, band 11q23.1 — between genes, 2.6 kb from SIK2.
What each result means
C/CTwo copies of the version the research linked to Allergic disease (asthma, hay fever or eczema). That is the strongest link of the three results. A link in a study is not a diagnosis.
C/TOne copy of the version the research linked to Allergic disease (asthma, hay fever or eczema). That is a smaller link than two copies.
T/TNo copy of the version the research linked to Allergic disease (asthma, hay fever or eczema). This is the starting point the study compared everyone against.
Nature genetics · 2017 · PMID 29083406 · open access
Questions about rs7130753
What is rs7130753?
rs7130753 is a single position in the genome, in or near the LAYN gene. Published research associates it with allergic disease (asthma, hay fever or eczema). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs7130753 linked to?
On MyGeneLog this position is linked to Asthma. The research behind each link, and its sources, are set out on that condition page.
Does having rs7130753 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs7130753 come from?
GWAS Catalog, Nature genetics 2017, PMID:29083406. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Allergic disease (asthma, hay fever or eczema) (rs7130753). MyGeneLog™. https://www.mygenelog.com/variants/rs7130753