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Life satisfaction

RFT1 · rs71301807

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

Strength of the evidence

1 / 4

Its strongest genetic-study result is p = 10⁻¹⁰, with 2 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10⁻⁵⁰. 2: ClinVar from one lab (1 star), or p ≤ 10⁻²⁰. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10⁻⁸). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 80,852 European ancestry individuals.

The effect Each copy of the G allele shifted the measure 0.00946 lower (95% confidence interval 0.0066-0.0124); p = 1 × 10⁻¹⁰.

How common The G allele had a frequency of about 24% in the people studied.

Where it sits Chromosome 3, band 3p21.1 — between genes, 4.7 kb from SFMBT1.

How common each version is

CG

Korean KRGDB

C 67.7% · G 32.4%

Korean Korea4K

C 66.7% · G 33.3%

Korean Korea1K

C 66.4% · G 33.6%

Japanese ToMMo

C 63.3% · G 36.7%

Vietnamese

C 85.0% · G 14.9%

World gnomAD

C 75.4% · G 24.6%

World 1000 Genomes

C 76.7% · G 23.3%

World TOPMed

C 74.7% · G 25.3%

By ancestry gnomAD

East Asian

C 74.2% · G 25.8%

European (non-Finnish)

C 75.5% · G 24.5%

African / African American

C 77.0% · G 23.1%

South Asian

C 87.5% · G 12.5%

Admixed American (Latino)

C 69.3% · G 30.6%

Middle Eastern

C 76.2% · G 23.8%

Finnish

C 74.5% · G 25.5%

Ashkenazi Jewish

C 69.7% · G 30.3%

The share of all copies of this position that are each version. Source: the population studies published in dbSNP (US NCBI); each row names its study. The ancestry rows are gnomAD's own groups (via Ensembl), as the survey defines them, not races.

What each result means

C/C No copy of the version the research linked to Life satisfaction. This is the starting point the study compared everyone against.

C/G One copy of the version the research linked to Life satisfaction. That is a smaller link than two copies.

G/G Two copies of the version the research linked to Life satisfaction. That is the strongest link of the three results. A link in a study is not a diagnosis.

Source

Multivariate genome-wide analyses of the well-being spectrum

Baselmans BML, Jansen R, Ip HF, van Dongen J, Abdellaoui A, van de Weijer MP, Bao Y, Smart M, Kumari M, Willemsen G, Hottenga JJ, Boomsma DI

and 3 more — show all

de Geus EJC, Nivard MG, Bartels M

BIOS consortium · Social Science Genetic Association Consortium

Nature genetics · 2019 · PMID 30643256

Quoting this page

Licensed CC BY-NC 4.0: free to read, share and adapt for non-commercial use, naming MyGeneLog™ and linking the exact page. Commercial use, including training or serving a commercial AI system, needs a licence — https://www.mygenelog.com/license

Life satisfaction (rs71301807). MyGeneLog™. https://www.mygenelog.com/variants/rs71301807

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