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Who was studied 327,435 European ancestry individuals, 5,845 African ancestry individuals, 6,425 South Asian ancestry individuals.
The effect
Each copy of the C allele shifted the measure 0.0974 lower (95% confidence interval 0.089-0.106); p = 1 × 10−104.
Where it sits Chromosome 11, band 11p15.2 — in an intron of CYP2R1.
What ClinVar records
Classificationassociation for Pulmonary disease, chronic obstructive, susceptibility to; no assertion criteria provided (0 of 4 stars, 1 submitter), last evaluated 2022-07-05.
ClinVar record 1693599NM_024514.5(CYP2R1):c.225+1110A>G
What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
What each result means
C/CTwo copies of the version the research linked to Vitamin D levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/TOne copy of the version the research linked to Vitamin D levels. That is a smaller link than two copies.
T/TNo copy of the version the research linked to Vitamin D levels. This is the starting point the study compared everyone against.
Nature genetics · 2021 · PMID 33462484 · open access
Questions about rs7129781
What is rs7129781?
rs7129781 is a single position in the genome, in or near the CYP2R1 gene. Published research associates it with vitamin d levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs7129781 linked to?
On MyGeneLog this position is linked to Gout. The research behind each link, and its sources, are set out on that condition page.
Does having rs7129781 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs7129781 come from?
GWAS Catalog, Nature genetics 2021, PMID:33462484. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 1412218Reads by AI crawlersClaude1ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon2Apple2China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others8Total14Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Vitamin D levels (rs7129781). MyGeneLog™. https://www.mygenelog.com/variants/rs7129781