Standard
Aortic root size
TMEM16A · rs7127129
Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What each result means
A/A
Published research associates this genotype with typical/baseline likelihood of Aortic root size — no copies of the reported risk allele.
A/G
Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Aortic root size.
G/G
Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Aortic root size compared to the general population.
Source
Large-scale genome-wide analysis identifies genetic variants associated with cardiac structure and function
Wild PS,
Felix JF,
Schillert A,
Teumer A,
Chen MH,
Leening MJG,
Völker U,
Großmann V,
Brody JA,
Irvin MR,
Shah SJ,
Pramana S
and 112 more — show all
Lieb W,
Schmidt R,
Stanton AV,
Malzahn D,
Smith AV,
Sundström J,
Minelli C,
Ruggiero D,
Lyytikäinen LP,
Tiller D,
Smith JG,
Monnereau C,
Di Tullio MR,
Musani SK,
Morrison AC,
Pers TH,
Morley M,
Kleber ME,
Aragam J,
Benjamin EJ,
Bis JC,
Bisping E,
Broeckel U,
Cheng S,
Deckers JW,
Del Greco M F,
Edelmann F,
Fornage M,
Franke L,
Friedrich N,
Harris TB,
Hofer E,
Hofman A,
Huang J,
Hughes AD,
Kähönen M,
Investigators K,
Kruppa J,
Lackner KJ,
Lannfelt L,
Laskowski R,
Launer LJ,
Leosdottir M,
Lin H,
Lindgren CM,
Loley C,
MacRae CA,
Mascalzoni D,
Mayet J,
Medenwald D,
Morris AP,
Müller C,
Müller-Nurasyid M,
Nappo S,
Nilsson PM,
Nuding S,
Nutile T,
Peters A,
Pfeufer A,
Pietzner D,
Pramstaller PP,
Raitakari OT,
Rice KM,
Rivadeneira F,
Rotter JI,
Ruohonen ST,
Sacco RL,
Samdarshi TE,
Schmidt H,
Sharp ASP,
Shields DC,
Sorice R,
Sotoodehnia N,
Stricker BH,
Surendran P,
Thom S,
Töglhofer AM,
Uitterlinden AG,
Wachter R,
Völzke H,
Ziegler A,
Münzel T,
März W,
Cappola TP,
Hirschhorn JN,
Mitchell GF,
Smith NL,
Fox ER,
Dueker ND,
Jaddoe VWV,
Melander O,
Russ M,
Lehtimäki T,
Ciullo M,
Hicks AA,
Lind L,
Gudnason V,
Pieske B,
Barron AJ,
Zweiker R,
Schunkert H,
Ingelsson E,
Liu K,
Arnett DK,
Psaty BM,
Blankenberg S,
Larson MG,
Felix SB,
Franco OH,
Zeller T,
Vasan RS,
Dörr M
The Journal of clinical investigation · 2017 · PMID 28394258
Questions about rs7127129
What is rs7127129?
rs7127129 is a single position in the genome, in or near the TMEM16A gene. Published research associates it with aortic root size. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs7127129 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs7127129 come from?
GWAS Catalog, J Clin Invest 2017, PMID:28394258. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
← See all variants