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Pre-treatment viral load in HIV-1 infection

ST14 · rs7126904

What the study found

Who was studied 1,398 European ancestry individuals, 572 Black individuals, 418 Hispanic individuals, 13 Asian ancestry individuals, 39 individuals.

The effect Each copy of the A allele shifted the measure 0.44 lower (95% confidence interval 0.35-0.54); p = 3 × 10−19.

How common The A allele had a frequency of about 7% in the people studied.

Where it sits Chromosome 11, band 11q24.3 — a missense change in ST14.

What ClinVar records

Classification Benign; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 2 submitters), last evaluated 2026-01-28. ClinVar record 1638220 NM_021978.4(ST14):c.855G>A (p.Met285Ile)

What this is ClinVar's aggregate record for this position (as of its 2026-10-12 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.

What each result means

A/A Two copies of the version the research linked to Pre-treatment viral load in HIV-1 infection. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Pre-treatment viral load in HIV-1 infection. That is a smaller link than two copies.
G/G No copy of the version the research linked to Pre-treatment viral load in HIV-1 infection. This is the starting point the study compared everyone against.
Source

Questions about rs7126904

What is rs7126904?

rs7126904 is a single position in the genome, in or near the ST14 gene. Published research associates it with pre-treatment viral load in hiv-1 infection. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs7126904 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs7126904 come from?

GWAS Catalog, The Journal of infectious diseases 2019, PMID:31219150. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Pre-treatment viral load in HIV-1 infection (rs7126904). MyGeneLog™. https://www.mygenelog.com/variants/rs7126904

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