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Contactin-5 levels

CNTN5 · rs7125241

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

Strength of the evidence

1 / 4

Its strongest genetic-study result is p = 10⁻¹¹, with 1 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10⁻⁵⁰. 2: ClinVar from one lab (1 star), or p ≤ 10⁻²⁰. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10⁻⁸). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 10,708 European ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.103 lower (95% confidence interval 0.074-0.132); p = 6 × 10⁻¹².

How common The A allele had a frequency of about 30% in the people studied.

Where it sits Chromosome 11, band 11q22.1 — in an intron of CNTN5.

What each result means

A/A Two copies of the version the research linked to Contactin-5 levels. That is the strongest link of the three results. A link in a study is not a diagnosis.

A/G One copy of the version the research linked to Contactin-5 levels. That is a smaller link than two copies.

G/G No copy of the version the research linked to Contactin-5 levels. This is the starting point the study compared everyone against.

Source

Mapping the proteo-genomic convergence of human diseases

Pietzner M, Wheeler E, Carrasco-Zanini J, Cortes A, Koprulu M, Wörheide MA, Oerton E, Cook J, Stewart ID, Kerrison ND, Luan J, Raffler J

and 9 more — show all

Arnold M, Arlt W, O'Rahilly S, Kastenmüller G, Gamazon ER, Hingorani AD, Scott RA, Wareham NJ, Langenberg C

Science (New York, N.Y.) · 2021 · PMID 34648354

Questions about rs7125241

What is rs7125241?

rs7125241 is a single position in the genome, in or near the CNTN5 gene. Published research associates it with contactin-5 levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs7125241 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs7125241 come from?

GWAS Catalog, Science (New York, N.Y.) 2021, PMID:34648354. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Contactin-5 levels (rs7125241). MyGeneLog™. https://www.mygenelog.com/variants/rs7125241

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