Sensitive

Ovarian cancer or hospitalized COVID-19 (pleiotropy)

PLEKHM1 · rs71238846

Where this position leads

Condition: Ovarian Cancer

rs71238846 Condition: Ovarian Cancer Ovarian Cancer Condition rs71238846 rs71238846 PLEKHM1

What the study found

Who was studied 22,406 European ancestry ovarian cancer cases, 32,519 European ancestry hospitalized COVID-19 cases, 2,103,746 European ancestry controls.

The effect The reported allele is A; the catalogue records no effect size ; p = 2 × 10−13.

Where it sits Chromosome 17, band 17q21.31 — a synonymous change in PLEKHM1.

What each result means

A/A Two copies of the version the research linked to Ovarian cancer or hospitalized COVID-19 (pleiotropy). That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Ovarian cancer or hospitalized COVID-19 (pleiotropy). That is a smaller link than two copies.
G/G No copy of the version the research linked to Ovarian cancer or hospitalized COVID-19 (pleiotropy). This is the starting point the study compared everyone against.
Source

Questions about rs71238846

What is rs71238846?

rs71238846 is a single position in the genome, in or near the PLEKHM1 gene. Published research associates it with ovarian cancer or hospitalized covid-19 (pleiotropy). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs71238846 linked to?

On MyGeneLog this position is linked to Ovarian Cancer. The research behind each link, and its sources, are set out on that condition page.

Does having rs71238846 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs71238846 come from?

GWAS Catalog, iScience 2023, PMID:37636041. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Ovarian cancer or hospitalized COVID-19 (pleiotropy) (rs71238846). MyGeneLog™. https://www.mygenelog.com/variants/rs71238846

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