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Hypothyroidism

TAGLN · rs7112573

Where this position leads

Condition: Hypothyroidism

rs7112573 Condition: Hypothyroidism Hypothyroidism Condition rs7112573 rs7112573 TAGLN

What the study found

Who was studied 51,194 European ancestry cases, 443,383 European ancestry controls; replicated in 17,002 cases, 178,141 controls.

The effect Each copy of the T allele shifted the measure 0.112 higher (95% confidence interval 0.08-0.144); p = 5 × 10−12.

Where it sits Chromosome 11, band 11q23.3 — in an intron of TAGLN.

What each result means

C/C No copy of the version the research linked to Hypothyroidism. This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to Hypothyroidism. That is a smaller link than two copies.
T/T Two copies of the version the research linked to Hypothyroidism. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs7112573

What is rs7112573?

rs7112573 is a single position in the genome, in or near the TAGLN gene. Published research associates it with hypothyroidism. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs7112573 linked to?

On MyGeneLog this position is linked to Hypothyroidism. The research behind each link, and its sources, are set out on that condition page.

Does having rs7112573 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs7112573 come from?

GWAS Catalog, iScience 2022, PMID:36093044. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Hypothyroidism (rs7112573). MyGeneLog™. https://www.mygenelog.com/variants/rs7112573

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