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Hodgkin's lymphoma

POU2AF1 · rs7111520

Where this position leads

Condition: Hodgkin Lymphoma

rs7111520 Condition: Hodgkin Lymphoma Hodgkin Lymphoma Condition rs7111520 rs7111520 POU2AF1

What the study found

Who was studied 5,325 European ancestry cases, 22,425 European ancestry controls.

The effect Each copy of the A allele carried 1.19 times the odds of Hodgkin's lymphoma (95% confidence interval 1.13-1.25); p = 1 × 10−11.

How common The A allele had a frequency of about 70% in the people studied.

Where it sits Chromosome 11, band 11q23.1 — in an intron of POU2AF1.

What each result means

A/A Two copies of the version the research linked to Hodgkin's lymphoma. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Hodgkin's lymphoma. That is a smaller link than two copies.
G/G No copy of the version the research linked to Hodgkin's lymphoma. This is the starting point the study compared everyone against.
Source

Questions about rs7111520

What is rs7111520?

rs7111520 is a single position in the genome, in or near the POU2AF1 gene. Published research associates it with hodgkin's lymphoma. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs7111520 linked to?

On MyGeneLog this position is linked to Hodgkin Lymphoma. The research behind each link, and its sources, are set out on that condition page.

Does having rs7111520 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs7111520 come from?

GWAS Catalog, Blood 2018, PMID:30194254. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Hodgkin's lymphoma (rs7111520). MyGeneLog™. https://www.mygenelog.com/variants/rs7111520

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