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Heart failure (MTAG)

SH3PXD2A · rs7101148

Where this position leads

Condition: Heart Failure

rs7101148 Condition: Heart Failure Heart Failure Condition rs7101148 rs7101148 SH3PXD2A

What the study found

Who was studied 358,418 European ancestry individuals.

The effect Each copy of the C allele shifted the measure 6.85 z-score higher; p = 7 × 10−12.

How common The C allele had a frequency of about 25% in the people studied.

Where it sits Chromosome 10, band 10q24.33 — in an intron of SH3PXD2A.

What each result means

C/C Two copies of the version the research linked to Heart failure (MTAG). That is the strongest link of the three results. A link in a study is not a diagnosis.
C/T One copy of the version the research linked to Heart failure (MTAG). That is a smaller link than two copies.
T/T No copy of the version the research linked to Heart failure (MTAG). This is the starting point the study compared everyone against.
Source

Questions about rs7101148

What is rs7101148?

rs7101148 is a single position in the genome, in or near the SH3PXD2A gene. Published research associates it with heart failure (mtag). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs7101148 linked to?

On MyGeneLog this position is linked to Heart Failure. The research behind each link, and its sources, are set out on that condition page.

Does having rs7101148 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs7101148 come from?

GWAS Catalog, NPJ genomic medicine 2025, PMID:41022758. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Heart failure (MTAG) (rs7101148). MyGeneLog™. https://www.mygenelog.com/variants/rs7101148

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