PLCE1 · rs7099485
Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.
Strength of the evidence
Its strongest genetic-study result is p = 10−8, with 1 associations in the GWAS Catalog.
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What the study found
Who was studied 1,686 Sub-Saharan African ancestry cases, 3,217 Sub-Saharan African ancestry controls, 2,013 East Asian ancestry cases, 2,701 East Asian ancestry controls.
The effect Each copy of the C allele carried 1.94 times the odds of Esophageal squamous cell carcinoma (95% confidence interval 1.86-2.03); p = 1 × 10−8.
Where it sits Chromosome 10, band 10q23.33 — in an intron of PLCE1.
rs7099485 is a single position in the genome, in or near the PLCE1 gene. Published research associates it with esophageal squamous cell carcinoma. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, American journal of human genetics 2023, PMID:37673066. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Esophageal squamous cell carcinoma (rs7099485). MyGeneLog™. https://www.mygenelog.com/variants/rs7099485