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FEV1

CAMK2G · rs7098573

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 321,047 European ancestry individuals; replicated in 79,005 European ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.0246 lower (95% confidence interval 0.02-0.03); p = 3 × 10⁻²¹.

How common The A allele had a frequency of about 72% in the people studied.

Where it sits Chromosome 10, band 10q22.2 — in an intron of CAMK2G.

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of FEV1 compared to the general population.

A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with FEV1.

G/G Published research associates this genotype with typical/baseline likelihood of FEV1 — no copies of the reported risk allele.

Source

New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries

Shrine N, Guyatt AL, Erzurumluoglu AM, Jackson VE, Hobbs BD, Melbourne CA, Batini C, Fawcett KA, Song K, Sakornsakolpat P, Li X, Boxall R

and 99 more — show all

Reeve NF, Obeidat M, Zhao JH, Wielscher M, Weiss S, Kentistou KA, Kentistou KA, Cook JP, Sun BB, Zhou J, Hui J, Karrasch S, Imboden M, Harris SE, Marten J, Enroth S, Kerr SM, Surakka I, Vitart V, Lehtimäki T, Allen RJ, Bakke PS, Beaty TH, Bleecker ER, Bossé Y, Brandsma CA, Chen Z, Crapo JD, Danesh J, DeMeo DL, Dudbridge F, Ewert R, Gieger C, Gulsvik A, Hansell AL, Hao K, Hoffman JD, Hokanson JE, Homuth G, Joshi PK, Joubert P, Langenberg C, Li X, Li L, Lin K, Lind L, Locantore N, Luan J, Mahajan A, Maranville JC, Murray A, Nickle DC, Packer R, Parker MM, Paynton ML, Porteous DJ, Porteous DJ, Prokopenko D, Qiao D, Rawal R, Runz H, Sayers I, Sin DD, Smith BH, Soler Artigas M, Sparrow D, Tal-Singer R, Timmers PRHJ, Van den Berge M, Whittaker JC, Woodruff PG, Yerges-Armstrong LM, Troyanskaya OG, Raitakari OT, Kähönen M, Polašek O, Gyllensten U, Rudan I, Deary IJ, Probst-Hensch NM, Schulz H, James AL, Wilson JF, Stubbe B, Zeggini E, Jarvelin MR, Wareham N, Silverman EK, Hayward C, Morris AP, Butterworth AS, Scott RA, Walters RG, Meyers DA, Cho MH, Strachan DP, Hall IP, Tobin MD, Wain LV

Understanding Society Scientific Group

Nature genetics · 2019 · PMID 30804560 · open access

Questions about rs7098573

What is rs7098573?

rs7098573 is a single position in the genome, in or near the CAMK2G gene. Published research associates it with fev1. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs7098573 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs7098573 come from?

GWAS Catalog, Nature genetics 2019, PMID:30804560. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

FEV1 (rs7098573). MyGeneLog™. https://www.mygenelog.com/variants/rs7098573

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