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Gut microbiota (bacterial taxa)

RP11-554I8.2 · rs7083345

Where this position leads

Condition: Gut Microbiota

rs7083345 Condition: Gut Microbiota Gut Microbiota Condition rs7083345 rs7083345 RP11-554I8.2

What the study found

Who was studied 1,812 European ancestry individuals.

The effect Each copy of the T allele shifted the measure 0.25 higher; p = 3 × 10−10.

Where it sits Chromosome 10, band 10p14 — between genes, 107 kb from LINC02665.

What each result means

C/C Published research associates this genotype with typical/baseline likelihood of Gut microbiota (bacterial taxa) — no copies of the reported risk allele.
C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Gut microbiota (bacterial taxa).
T/T Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Gut microbiota (bacterial taxa) compared to the general population.
Source
Genome-wide association analysis identifies variation in vitamin D receptor and other host factors influencing the gut microbiota
Wang J, Thingholm LB, Skiecevičienė J, Rausch P, Kummen M, Hov JR, Degenhardt F, Heinsen FA, Rühlemann MC, Szymczak S, Holm K, Esko T
and 27 more — show all
Sun J, Pricop-Jeckstadt M, Al-Dury S, Bohov P, Bethune J, Sommer F, Ellinghaus D, Berge RK, Hübenthal M, Koch M, Schwarz K, Rimbach G, Hübbe P, Pan WH, Sheibani-Tezerji R, Häsler R, Rosenstiel P, D'Amato M, Cloppenborg-Schmidt K, Künzel S, Laudes M, Marschall HU, Lieb W, Nöthlings U, Karlsen TH, Baines JF, Franke A
Nature genetics · 2016 · PMID 27723756

Questions about rs7083345

What is rs7083345?

rs7083345 is a single position in the genome, in or near the RP11-554I8.2 gene. Published research associates it with gut microbiota (bacterial taxa). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs7083345 linked to?

On MyGeneLog this position is linked to Gut Microbiota. The research behind each link, and its sources, are set out on that condition page.

Does having rs7083345 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs7083345 come from?

GWAS Catalog, Nature genetics 2016, PMID:27723756. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Gut microbiota (bacterial taxa) (rs7083345). MyGeneLog™. https://www.mygenelog.com/variants/rs7083345

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