Standard

Mean corpuscular volume

NT5C2 · rs7067663

Where this position leads

Condition: Blood Cell Counts

rs7067663 Condition: Blood Cell Counts Blood Cell Counts Condition rs7067663 rs7067663 NT5C2

Strength of the evidence

2 / 4

Its strongest genetic-study result is p = 10−26, with 1 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 350,473 European ancestry individuals, 129,832 East Asian ancestry individuals.

The effect Each copy of the G allele shifted the measure 0.0239 lower (95% confidence interval 0.02-0.028); p = 8 × 10−27.

Where it sits Chromosome 10, band 10q24.33 — in an intron of NT5C2.

What each result means

A/A No copy of the version the research linked to Mean corpuscular volume. This is the starting point the study compared everyone against.
A/G One copy of the version the research linked to Mean corpuscular volume. That is a smaller link than two copies.
G/G Two copies of the version the research linked to Mean corpuscular volume. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs7067663

What is rs7067663?

rs7067663 is a single position in the genome, in or near the NT5C2 gene. Published research associates it with mean corpuscular volume. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs7067663 linked to?

On MyGeneLog this position is linked to Blood Cell Counts. The research behind each link, and its sources, are set out on that condition page.

Does having rs7067663 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs7067663 come from?

GWAS Catalog, Nature genetics 2021, PMID:34594039. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Licensed CC BY-NC 4.0: free to read, share and adapt for non-commercial use, naming MyGeneLog™ and linking the exact page. Commercial use, including training or serving a commercial AI system, needs a licence — https://www.mygenelog.com/license

Mean corpuscular volume (rs7067663). MyGeneLog™. https://www.mygenelog.com/variants/rs7067663

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