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Intraocular pressure

GLIS3 · rs7047871

Where this position leads

Condition: Intraocular Pressure

What the study found

Who was studied 5,571 Chinese ancestry individuals; replicated in 2,981 Chinese ancestry individuals.

The effect Each copy of the T allele shifted the measure 8.54 z score lower; p = 1 × 10⁻¹⁷.

How common The T allele had a frequency of about 69% in the people studied.

Where it sits Chromosome 9, band 9p24.2 — in an intron of GLIS3.

What each result means

A/A Published research associates this genotype with typical/baseline likelihood of Intraocular pressure — no copies of the reported risk allele.

A/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Intraocular pressure.

T/T Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Intraocular pressure compared to the general population.

Source

Genome-wide analysis identified 17 new loci influencing intraocular pressure in Chinese population

Huang L, Chen Y, Lin Y, Tam POS, Cheng Y, Shi Y, Gong B, Lu F, Yang J, Wang H, Yin Y, Cao Y

and 9 more — show all

Jiang D, Zhong L, Xue B, Wang J, Hao F, Lee DY, Pang CP, Sun X, Yang Z

Science China. Life sciences · 2019 · PMID 30591961

Questions about rs7047871

What is rs7047871?

rs7047871 is a single position in the genome, in or near the GLIS3 gene. Published research associates it with intraocular pressure. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs7047871 linked to?

On MyGeneLog this position is linked to Intraocular Pressure. The research behind each link, and its sources, are set out on that condition page.

Does having rs7047871 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs7047871 come from?

GWAS Catalog, Science China. Life sciences 2019, PMID:30591961. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Intraocular pressure (rs7047871). MyGeneLog™. https://www.mygenelog.com/variants/rs7047871

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