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Asthma

GLIS3 · rs7041606

Where this position leads

Condition: Asthma

rs7041606 Condition: Asthma Asthma Condition rs7041606 rs7041606 GLIS3

What the study found

Who was studied 13,015 East Asian ancestry cases, 162,933 East Asian ancestry controls.

The effect Each copy of the C allele shifted the measure 0.092 higher (95% confidence interval 0.063-0.121); p = 5 × 10−10.

How common The C allele had a frequency of about 31% in the people studied.

Where it sits Chromosome 9, band 9p24.2 — in an intron of GLIS3.

What each result means

C/C Two copies of the version the research linked to Asthma. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/G One copy of the version the research linked to Asthma. That is a smaller link than two copies.
G/G No copy of the version the research linked to Asthma. This is the starting point the study compared everyone against.
Source
A cross-population atlas of genetic associations for 220 human phenotypes
Sakaue S, Kanai M, Tanigawa Y, Karjalainen J, Kurki M, Koshiba S, Narita A, Konuma T, Yamamoto K, Akiyama M, Ishigaki K, Suzuki A
and 34 more — show all
Suzuki K, Obara W, Yamaji K, Takahashi K, Asai S, Takahashi Y, Suzuki T, Shinozaki N, Yamaguchi H, Minami S, Murayama S, Yoshimori K, Nagayama S, Obata D, Higashiyama M, Masumoto A, Koretsune Y, Ito K, Terao C, Yamauchi T, Komuro I, Kadowaki T, Tamiya G, Yamamoto M, Nakamura Y, Kubo M, Murakami Y, Yamamoto K, Kamatani Y, Palotie A, Rivas MA, Daly MJ, Matsuda K, Okada Y
FinnGen
Nature genetics · 2021 · PMID 34594039

Questions about rs7041606

What is rs7041606?

rs7041606 is a single position in the genome, in or near the GLIS3 gene. Published research associates it with asthma. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs7041606 linked to?

On MyGeneLog this position is linked to Asthma. The research behind each link, and its sources, are set out on that condition page.

Does having rs7041606 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs7041606 come from?

GWAS Catalog, Nature genetics 2021, PMID:34594039. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Asthma (rs7041606). MyGeneLog™. https://www.mygenelog.com/variants/rs7041606

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