ZMIZ1 · rs703977
Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.
Strength of the evidence
Its strongest genetic-study result is p = 10−23, with 2 associations in the GWAS Catalog.
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What the study found
Who was studied 16,718 African American or Afro-Caribbean cases, 38,787 African American or Afro-Caribbean controls, 8,910 Hispanic or Latin American cases, 20,404 Hispanic or Latin American controls, 1,007 East Asian ancestry cases, 2,540 East Asian ancestry controls, 80,160 European ancestry cases, 235,508 European ancestry controls.
The effect Each copy of the T allele shifted the measure 0.0616 higher (95% confidence interval 0.049-0.074); p = 3 × 10−23.
How common The T allele had a frequency of about 58% in the people studied.
Where it sits Chromosome 10, band 10q22.3 — in an intron of ZMIZ1.
What ClinVar records
Classification
Benign; criteria provided, single submitter (1 of 4 stars, 1 submitter), last evaluated 2020-02-18.
ClinVar record 1281699 NM_020338.4(ZMIZ1):c.-49-17111T>G
Change history MyGeneLog™ keeps a copy of every weekly release from 2026-10-19 and compares them. This position's classification has not changed since.
What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
How common each version is
GT
G 41.7% · T 58.3%
G 41.0% · T 59.0%
G 42.6% · T 57.4%
G 44.0% · T 56.0%
G 30.7% · T 69.3%
G 39.8% · T 60.2%
G 37.4% · T 62.6%
G 39.0% · T 61.0%
The share of all copies of this position that are each version. Source: the population studies published in dbSNP (US NCBI); each row names its study.
rs703977 is a single position in the genome, in or near the ZMIZ1 gene. Published research associates it with diabetes / "sugar". A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Science (New York, N.Y.) 2024, PMID:39024449. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Licensed CC BY-NC 4.0: free to read, share and adapt for non-commercial use, naming MyGeneLog™ and linking the exact page. Commercial use, including training or serving a commercial AI system, needs a licence — https://www.mygenelog.com/license
Diabetes / "Sugar" (rs703977). MyGeneLog™. https://www.mygenelog.com/variants/rs703977