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Who was studied 12,019 European ancestry cases, 1,869,646 European ancestry controls.
The effect
Each copy of the C allele shifted the measure 0.081 higher (95% confidence interval 0.052-0.11); p = 3 × 10−8.
How common The C allele had a frequency of about 34% in the people studied.
Where it sits Chromosome 9, band 9q33.2 — in an intron of TRAF1.
What each result means
C/CTwo copies of the version the research linked to Graves' disease. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/GOne copy of the version the research linked to Graves' disease. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Graves' disease. This is the starting point the study compared everyone against.
Nature genetics · 2026 · PMID 41644669 · open access
Questions about rs7021880
What is rs7021880?
rs7021880 is a single position in the genome, in or near the TRAF1 gene. Published research associates it with graves' disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs7021880 linked to?
On MyGeneLog this position is linked to Graves' Disease. The research behind each link, and its sources, are set out on that condition page.
Does having rs7021880 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs7021880 come from?
GWAS Catalog, Nature genetics 2026, PMID:41644669. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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