Sensitive

Hirschsprung disease

NRG1 · rs7005606

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What each result means

G/G Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Hirschsprung disease compared to the general population. (GWAS Catalog, Hum Mol Genet 2016, PMID:27702942)

G/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Hirschsprung disease. (GWAS Catalog, Hum Mol Genet 2016, PMID:27702942)

T/T Published research associates this genotype with typical/baseline likelihood of Hirschsprung disease — no copies of the reported risk allele. (GWAS Catalog, Hum Mol Genet 2016, PMID:27702942)

Source: GWAS Catalog, Hum Mol Genet 2016, PMID:27702942

Questions about rs7005606

What is rs7005606?

rs7005606 is a single position in the genome, in or near the NRG1 gene. Published research associates it with hirschsprung disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs7005606 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs7005606 come from?

GWAS Catalog, Hum Mol Genet 2016, PMID:27702942. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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