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Corneal curvature

near PKIA-AS1 · rs7004112

What the study found

Who was studied 29,580 European ancestry individuals, 14,462 Asian ancestry individuals; replicated in 88,218 European ancestry individuals.

The effect Each copy of the T allele shifted the measure 0.014 mm lower; p = 6 × 10−38.

How common The T allele had a frequency of about 37% in the people studied.

Where it sits Chromosome 8, band 8q21.13 — between genes, 138.5 kb from PKIA-AS1.

What each result means

G/G No copy of the version the research linked to Corneal curvature. This is the starting point the study compared everyone against.
G/T One copy of the version the research linked to Corneal curvature. That is a smaller link than two copies.
T/T Two copies of the version the research linked to Corneal curvature. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs7004112

What is rs7004112?

rs7004112 is a single position in the genome, in or near the near PKIA-AS1 gene. Published research associates it with corneal curvature. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs7004112 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs7004112 come from?

GWAS Catalog, Communications biology 2020, PMID:32193507. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Corneal curvature (rs7004112). MyGeneLog™. https://www.mygenelog.com/variants/rs7004112

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