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Aortic valve peak velocity (MTAG)

ZFPM2 · rs7001844

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 96,385 European ancestry individuals (MTAG effective sample size boosted by aortic valve function and stenosis samples).

The effect Each copy of the T allele shifted the measure 0.0374 lower (95% confidence interval 0.026-0.049); p = 2 × 10⁻¹⁰.

How common The T allele had a frequency of about 81% in the people studied.

Where it sits Chromosome 8, band 8q22.3 — inside ZFPM2.

What each result means

C/C Published research associates this genotype with typical/baseline likelihood of Aortic valve peak velocity (MTAG) — no copies of the reported risk allele.

C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Aortic valve peak velocity (MTAG).

T/T Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Aortic valve peak velocity (MTAG) compared to the general population.

Source

Multitrait analyses identify genetic variants associated with aortic valve function and aortic stenosis risk

Kany S, Rämö JT, Hou C, Jurgens SJ, Khurshid S, Nauffal V, Cunningham JW, Lau ES, Koyama S, Ho JE, Olgin JE, Elmariah S

and 4 more — show all

Palotie A, Lindsay ME, Ellinor PT, Pirruccello JP

FinnGen

Nature genetics · 2026 · PMID 41419685 · open access

Questions about rs7001844

What is rs7001844?

rs7001844 is a single position in the genome, in or near the ZFPM2 gene. Published research associates it with aortic valve peak velocity (mtag). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs7001844 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs7001844 come from?

GWAS Catalog, Nature genetics 2026, PMID:41419685. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Aortic valve peak velocity (MTAG) (rs7001844). MyGeneLog™. https://www.mygenelog.com/variants/rs7001844

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