Sensitive

Bipolar disorder (MTAG)

LETM2 · rs7001340

Where this position leads

What the study found

Who was studied at least 20,352 European ancestry cases, at least 31,358 European ancestry controls.

The effect Each copy of the T allele shifted the measure 0.0748 higher (95% confidence interval 0.049-0.1); p = 1 × 10⁻⁸.

How common The T allele had a frequency of about 76% in the people studied.

Where it sits Chromosome 8, band 8p11.23 — in an intron of LETM2.

What ClinVar records

Classification Benign; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 2 submitters), last evaluated 2020-10-29. ClinVar record 1261324 NM_001286819.2(LETM2):c.1218+209T>C

What this is ClinVar's aggregate record for this position (as of its 2026-10-12 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.

What each result means

C/C No copy of the version the research linked to Bipolar disorder (MTAG). This is the starting point the study compared everyone against.

C/T One copy of the version the research linked to Bipolar disorder (MTAG). That is a smaller link than two copies.

T/T Two copies of the version the research linked to Bipolar disorder (MTAG). That is the strongest link of the three results. A link in a study is not a diagnosis.

Source

Integrative analysis of genome-wide association studies identifies novel loci associated with neuropsychiatric disorders

Yao X, Glessner JT, Li J, Qi X, Hou X, Zhu C, Li X, March ME, Yang L, Mentch FD, Hain HS, Meng X

and 3 more — show all

Xia Q, Hakonarson H, Li J

Translational psychiatry · 2021 · PMID 33479212 · open access

Questions about rs7001340

What is rs7001340?

rs7001340 is a single position in the genome, in or near the LETM2 gene. Published research associates it with bipolar disorder (mtag). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs7001340 linked to?

On MyGeneLog this position is linked to Bipolar Disorder. The research behind each link, and its sources, are set out on that condition page.

Does having rs7001340 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs7001340 come from?

GWAS Catalog, Translational psychiatry 2021, PMID:33479212. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Bipolar disorder (MTAG) (rs7001340). MyGeneLog™. https://www.mygenelog.com/variants/rs7001340

← See all variants