Standard

HDL cholesterol levels

ZFPM2 · rs6987377

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

Strength of the evidence

1 / 4

Its strongest genetic-study result is p = 10⁻⁸, with 1 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10⁻⁵⁰. 2: ClinVar from one lab (1 star), or p ≤ 10⁻²⁰. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10⁻⁸). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 403,943 European ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.0111 lower (95% confidence interval 0.0073-0.0149); p = 1 × 10⁻⁸.

How common The A allele had a frequency of about 42% in the people studied.

Where it sits Chromosome 8, band 8q23.1 — in an intron of ZFPM2-AS1.

What each result means

A/A Two copies of the version the research linked to HDL cholesterol levels. That is the strongest link of the three results. A link in a study is not a diagnosis.

A/G One copy of the version the research linked to HDL cholesterol levels. That is a smaller link than two copies.

G/G No copy of the version the research linked to HDL cholesterol levels. This is the starting point the study compared everyone against.

Source

Evaluating the relationship between circulating lipoprotein lipids and apolipoproteins with risk of coronary heart disease: A multivariable Mendelian randomisation analysis

Richardson TG, Sanderson E, Palmer TM, Ala-Korpela M, Ference BA, Davey Smith G, Holmes MV

PLoS medicine · 2020 · PMID 32203549 · open access

Questions about rs6987377

What is rs6987377?

rs6987377 is a single position in the genome, in or near the ZFPM2 gene. Published research associates it with hdl cholesterol levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs6987377 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs6987377 come from?

GWAS Catalog, PLoS medicine 2020, PMID:32203549. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Licensed CC BY-NC 4.0: free to read, share and adapt for non-commercial use, naming MyGeneLog™ and linking the exact page. Commercial use, including training or serving a commercial AI system, needs a licence — https://www.mygenelog.com/license

HDL cholesterol levels (rs6987377). MyGeneLog™. https://www.mygenelog.com/variants/rs6987377

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