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Inguinal hernia

EBF2 · rs6983815

Where this position leads

Condition: Inguinal Hernia

rs6983815 Condition: Inguinal Hernia Inguinal Hernia Condition rs6983815 rs6983815 EBF2

What the study found

Who was studied 18,791 European ancestry cases, 93,955 European ancestry controls.

The effect Each copy of the A allele carried 1.19 times the odds of Inguinal hernia (95% confidence interval 1.17-1.22); p = 1 × 10−54.

How common The A allele had a frequency of about 41% in the people studied.

Where it sits Chromosome 8, band 8p21.2 — in an intron of EBF2.

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Inguinal hernia compared to the general population.
A/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Inguinal hernia.
T/T Published research associates this genotype with typical/baseline likelihood of Inguinal hernia — no copies of the reported risk allele.
Source
Shared genetic architecture of hernias: A genome-wide association study with multivariable meta-analysis of multiple hernia phenotypes
Ahmed WU, Patel MIA, Ng M, McVeigh J, Zondervan K, Wiberg A, Furniss D
PloS one · 2022 · PMID 36584111 · open access

Questions about rs6983815

What is rs6983815?

rs6983815 is a single position in the genome, in or near the EBF2 gene. Published research associates it with inguinal hernia. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs6983815 linked to?

On MyGeneLog this position is linked to Inguinal Hernia. The research behind each link, and its sources, are set out on that condition page.

Does having rs6983815 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs6983815 come from?

GWAS Catalog, PloS one 2022, PMID:36584111. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Inguinal hernia (rs6983815). MyGeneLog™. https://www.mygenelog.com/variants/rs6983815

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