Standard
High density lipoprotein cholesterol levels
near KLF14 · rs6974288
Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 62,138 Hispanic or Latino individuals.
The effect
Each copy of the A allele shifted the measure 0.0366 lower (95% confidence interval 0.017-0.056); p = 1 × 10−12.
How common The A allele had a frequency of about 62% in the people studied.
Where it sits Chromosome 7, band 7q32.2 — between genes, 5.2 kb from KLF14.
What each result means
A/A
Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of High density lipoprotein cholesterol levels compared to the general population.
A/G
Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with High density lipoprotein cholesterol levels.
G/G
Published research associates this genotype with typical/baseline likelihood of High density lipoprotein cholesterol levels — no copies of the reported risk allele.
Source
Large-scale multi-omics analyses in Hispanic/Latino populations identify genes for cardiometabolic traits
Petty LE,
Chen HH,
Frankel EG,
Zhu W,
Downie CG,
Graff M,
Lin P,
Sharma P,
Zhang X,
Scartozzi AC,
Roshani R,
Landman JM
and 80 more — show all
Boehnke M,
Bowden DW,
Chambers JC,
Mahajan A,
McCarthy MI,
Ng MCY,
Sim X,
Spracklen CN,
Zhang W,
Preuss M,
Bottinger EP,
Nadkarni GN,
Loos RJF,
Chen YI,
Tan J,
Ipp E,
Genter P,
Emery LS,
Louie T,
Sofer T,
Stilp AM,
Taylor KD,
Xiang AH,
Buchanan TA,
Roll K,
Gao C,
Palmer ND,
Norris JM,
Wagenknecht LE,
Nousome D,
Varma R,
McKean-Cowdin R,
Guo X,
Hai Y,
Hsueh W,
Sandow K,
Parra EJ,
Cruz M,
Valladares-Salgado A,
Wacher-Rodarte N,
Rotter JI,
Goodarzi MO,
Rich SS,
Bertoni A,
Raffel LJ,
Nadler JL,
Kandeel FR,
Duggirala R,
Blangero J,
Lehman DM,
DeFronzo RA,
Thameem F,
Wang Y,
Gahagan S,
Blanco E,
Burrows R,
Huerta-Chagoya A,
Florez JC,
Tusie-Luna T,
González-Villalpando C,
Orozco L,
Haiman CA,
Hanis CL,
Rohde R,
Whitsel EA,
Reiner AP,
Kooperberg C,
Li Y,
Duan Q,
Lee M,
Correa-Burrows P,
Fried SK,
North KE,
McCormick JB,
Fisher-Hoch SP,
Gamazon ER,
Morris AP,
Mercader JM,
Highland HM,
Below JE
Nature communications · 2025 · PMID 40210677 · open access
Questions about rs6974288
What is rs6974288?
rs6974288 is a single position in the genome, in or near the near KLF14 gene. Published research associates it with high density lipoprotein cholesterol levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs6974288 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs6974288 come from?
GWAS Catalog, Nature communications 2025, PMID:40210677. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
High density lipoprotein cholesterol levels (rs6974288). MyGeneLog™. https://www.mygenelog.com/variants/rs6974288
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