Sensitive

Breast cancer

AKAP9 · rs6964587

Where this position leads

What the study found

Who was studied 24,206 East Asian ancestry cases, 24,775 East Asian ancestry controls, 122,977 European ancestry cases, 105,974 European ancestry controls; replicated in 10,829 East Asian ancestry cases, 10,996 East Asian ancestry controls, 5,958 Asian ancestry cases, 5,684 Asian ancestry controls.

The effect Each copy of the T allele carried 1.04 times the odds of Breast cancer (95% confidence interval 1.03-1.05); p = 3 × 10⁻¹².

Where it sits Chromosome 7, band 7q21.2 — a missense change in AKAP9.

What ClinVar records

Classification Benign for Colorectal cancer, Cardiovascular phenotype, Long QT syndrome, Long QT syndrome 11; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 15 submitters), last evaluated 2026-02-04. ClinVar record 136347 NM_005751.5(AKAP9):c.1389G>T (p.Met463Ile)

What this is ClinVar's aggregate record for this position (as of its 2026-10-12 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.

What each result means

G/G No copy of the version the research linked to Breast cancer. This is the starting point the study compared everyone against.

G/T One copy of the version the research linked to Breast cancer. That is a smaller link than two copies.

T/T Two copies of the version the research linked to Breast cancer. That is the strongest link of the three results. A link in a study is not a diagnosis.

Source

Identification of novel breast cancer susceptibility loci in meta-analyses conducted among Asian and European descendants

Shu X, Long J, Cai Q, Kweon SS, Choi JY, Kubo M, Park SK, Bolla MK, Dennis J, Wang Q, Yang Y, Shi J

and 50 more — show all

Guo X, Li B, Tao R, Aronson KJ, Chan KYK, Chan TL, Gao YT, Hartman M, Kee Ho W, Ito H, Iwasaki M, Iwata H, John EM, Kasuga Y, Soon Khoo U, Kim MK, Kong SY, Kurian AW, Kwong A, Lee ES, Li J, Lophatananon A, Low SK, Mariapun S, Matsuda K, Matsuo K, Muir K, Noh DY, Park B, Park MH, Shen CY, Shin MH, Spinelli JJ, Takahashi A, Tseng C, Tsugane S, Wu AH, Xiang YB, Yamaji T, Zheng Y, Milne RL, Dunning AM, Pharoah PDP, García-Closas M, Teo SH, Shu XO, Kang D, Easton DF, Simard J, Zheng W

Nature communications · 2020 · PMID 32139696 · open access

Questions about rs6964587

What is rs6964587?

rs6964587 is a single position in the genome, in or near the AKAP9 gene. Published research associates it with breast cancer. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs6964587 linked to?

On MyGeneLog this position is linked to Breast Cancer. The research behind each link, and its sources, are set out on that condition page.

Does having rs6964587 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs6964587 come from?

GWAS Catalog, Nature communications 2020, PMID:32139696. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Breast cancer (rs6964587). MyGeneLog™. https://www.mygenelog.com/variants/rs6964587

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