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C-reactive protein levels

near ZNF655 · rs6961634

Where this position leads

Condition: C-Reactive Protein Levels

rs6961634 Condition: C-Reactive Protein Levels C-Reactive Protein Levels Condition rs6961634 rs6961634 near ZNF655

What the study found

Who was studied 418,642 British ancestry individuals.

The effect Each copy of the G allele shifted the measure 0.0274 higher (95% confidence interval 0.022-0.033); p = 2 × 10−20.

How common The G allele had a frequency of about 85% in the people studied.

Where it sits Chromosome 7, band 7q22.1 — between genes, 7.8 kb from ZNF655.

What each result means

A/A Published research associates this genotype with typical/baseline likelihood of C-reactive protein levels — no copies of the reported risk allele.
A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with C-reactive protein levels.
G/G Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of C-reactive protein levels compared to the general population.
Source
Using Mendelian randomization to evaluate the causal relationship between serum C-reactive protein levels and age-related macular degeneration
Han X, Ong JS, An J, Hewitt AW, Gharahkhani P, MacGregor S
European journal of epidemiology · 2020 · PMID 31900758

Questions about rs6961634

What is rs6961634?

rs6961634 is a single position in the genome, in or near the near ZNF655 gene. Published research associates it with c-reactive protein levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs6961634 linked to?

On MyGeneLog this position is linked to C-Reactive Protein Levels. The research behind each link, and its sources, are set out on that condition page.

Does having rs6961634 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs6961634 come from?

GWAS Catalog, European journal of epidemiology 2020, PMID:31900758. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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C-reactive protein levels (rs6961634). MyGeneLog™. https://www.mygenelog.com/variants/rs6961634

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