Sensitive

Plasma proprotein convertase subtilisin/kexin type 9 levels in stable coronary artery disease

FBXL18 · rs6957201

Where this position leads

Condition: Coronary Artery Disease

rs6957201 Condition: Coronary Artery Disease Coronary Artery Disease Condition rs6957201 rs6957201 FBXL18

What the study found

Who was studied 2,022 European ancestry individuals without statin treatment, 1,268 European ancestry individuals with statin treatment.

The effect Each copy of the C allele shifted the measure 0.163 lower (95% confidence interval 0.11-0.22); p = 7 × 10−9.

How common The C allele had a frequency of about 97% in the people studied.

Where it sits Chromosome 7, band 7p22.1 — in an intron of LINC03073.

What each result means

C/C Two copies of the version the research linked to Plasma proprotein convertase subtilisin/kexin type 9 levels in stable coronary artery disease. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/T One copy of the version the research linked to Plasma proprotein convertase subtilisin/kexin type 9 levels in stable coronary artery disease. That is a smaller link than two copies.
T/T No copy of the version the research linked to Plasma proprotein convertase subtilisin/kexin type 9 levels in stable coronary artery disease. This is the starting point the study compared everyone against.
Source

Questions about rs6957201

What is rs6957201?

rs6957201 is a single position in the genome, in or near the FBXL18 gene. Published research associates it with plasma proprotein convertase subtilisin/kexin type 9 levels in stable coronary artery disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs6957201 linked to?

On MyGeneLog this position is linked to Coronary Artery Disease. The research behind each link, and its sources, are set out on that condition page.

Does having rs6957201 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs6957201 come from?

GWAS Catalog, Circulation. Genomic and precision medicine 2018, PMID:29748315. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Plasma proprotein convertase subtilisin/kexin type 9 levels in stable coronary artery disease (rs6957201). MyGeneLog™. https://www.mygenelog.com/variants/rs6957201

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