Sensitive

Chronotype and breast cancer

TTC28 · rs695459

Where this position leads

Condition: Breast Cancer

rs695459 Condition: Breast Cancer Breast Cancer Condition rs695459 rs695459 TTC28

What the study found

Who was studied 133,384 European ancestry breast cancer cases, 113,789 European ancestry controls, 449,734 European ancestry individuals.

The effect The reported allele is C; the catalogue records no effect size ; p = 6 × 10−10.

Where it sits Chromosome 22, band 22q12.1 — in an intron of TTC28.

What each result means

C/C Two copies of the version the research linked to Chronotype and breast cancer. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/T One copy of the version the research linked to Chronotype and breast cancer. That is a smaller link than two copies.
T/T No copy of the version the research linked to Chronotype and breast cancer. This is the starting point the study compared everyone against.
Source

Questions about rs695459

What is rs695459?

rs695459 is a single position in the genome, in or near the TTC28 gene. Published research associates it with chronotype and breast cancer. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs695459 linked to?

On MyGeneLog this position is linked to Breast Cancer. The research behind each link, and its sources, are set out on that condition page.

Does having rs695459 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs695459 come from?

GWAS Catalog, Journal of sleep research 2024, PMID:37380357. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Chronotype and breast cancer (rs695459). MyGeneLog™. https://www.mygenelog.com/variants/rs695459

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