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Standard

High density lipoprotein cholesterol levels

near MRM3P2 · rs6952559

Strength of the evidence

1 / 4

Its strongest genetic-study result is p = 10−8, with 1 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 99,432 Admixed African or African ancestry individuals.

The effect Each copy of the C allele shifted the measure 0.0363 higher (95% confidence interval 0.024-0.049); p = 1 × 10−8.

How common The C allele had a frequency of about 18% in the people studied.

Where it sits Chromosome 7, band 7p21.1 — between genes, 27.5 kb from MRM3P2.

How common each version is

CT
Korean KRGDB
C 29.7% · T 70.3%
Korean Korea4K
C 30.0% · T 70.0%
Korean Korea1K
C 29.6% · T 70.4%
Japanese ToMMo
C 34.2% · T 65.8%
Vietnamese
C 25.2% · T 74.8%
World gnomAD
C 43.9% · T 56.1%
World 1000 Genomes
C 33.2% · T 66.8%
World TOPMed
C 42.0% · T 58.0%

The share of all copies of this position that are each version. Source: the population studies published in dbSNP (US NCBI); each row names its study.

What each result means

C/C Two copies of the version the research linked to High density lipoprotein cholesterol levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/T One copy of the version the research linked to High density lipoprotein cholesterol levels. That is a smaller link than two copies.
T/T No copy of the version the research linked to High density lipoprotein cholesterol levels. This is the starting point the study compared everyone against.
Source

Quoting this page

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High density lipoprotein cholesterol levels (rs6952559). MyGeneLog™. https://www.mygenelog.com/variants/rs6952559

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