HDAC9 · rs6950598
Where this position leads
Condition: Colorectal Cancer
Strength of the evidence
Its strongest genetic-study result is p = 10−9.
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What the study found
Who was studied 590 European ancestry cases, 55 Black cases, 9 Hispanic cases, 28 Asian ancestry cases, 5 cases, 12,715 European ancestry controls, 1,153 Black controls, 37 Hispanic controls, 94 Asian ancestry controls, 15 controls.
The effect Each copy of the C allele carried 0.88 times the odds of Colorectal cancer x fine particulate matter exposure levels interaction (95% confidence interval 0.84-0.92); p = 2 × 10−9.
How common The C allele had a frequency of about 20% in the people studied.
Where it sits Chromosome 7, band 7p21.1 — in an intron of HDAC9.
How common each version is
CG
C 38.6% · G 61.4%
C 37.5% · G 62.5%
C 37.8% · G 62.2%
C 47.0% · G 53.0%
C 31.0% · G 69.0%
C 17.8% · G 82.2%
C 19.8% · G 80.2%
C 18.7% · G 81.3%
The share of all copies of this position that are each version. Source: the population studies published in dbSNP (US NCBI); each row names its study.
rs6950598 is a single position in the genome, in or near the HDAC9 gene. Published research associates it with colorectal cancer x fine particulate matter exposure levels interaction. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Colorectal Cancer. The research behind each link, and its sources, are set out on that condition page.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Environ Int 2020, PMID:33338681. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Colorectal cancer x fine particulate matter exposure levels interaction (rs6950598). MyGeneLog™. https://www.mygenelog.com/variants/rs6950598