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Atrial fibrillation (PheCode 427.21)

CDK6 · rs6948097

Where this position leads

Condition: Atrial Fibrillation

rs6948097 Condition: Atrial Fibrillation Atrial Fibrillation Condition rs6948097 rs6948097 CDK6

What the study found

Who was studied 8,873 African American or Afro-Caribbean cases, 109,974 African American or Afro-Caribbean controls, 4,063 Hispanic or Latin American cases, 54,799 Hispanic or Latin American controls, 397 East Asian ancestry cases, 6,355 East Asian ancestry controls, 71,577 European ancestry cases, 366,195 European ancestry controls.

The effect Each copy of the C allele shifted the measure 0.0553 higher (95% confidence interval 0.041-0.07); p = 4 × 10−15.

How common The C allele had a frequency of about 76% in the people studied.

Where it sits Chromosome 7, band 7q21.2 — in an intron of CDK6.

What each result means

C/C Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Atrial fibrillation (PheCode 427.21) compared to the general population.
C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Atrial fibrillation (PheCode 427.21).
T/T Published research associates this genotype with typical/baseline likelihood of Atrial fibrillation (PheCode 427.21) — no copies of the reported risk allele.
Source
Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program
Verma A, Huffman JE, Rodriguez A, Conery M, Liu M, Ho YL, Kim Y, Heise DA, Guare L, Panickan VA, Garcon H, Linares F
and 59 more — show all
Costa L, Goethert I, Tipton R, Honerlaw J, Davies L, Whitbourne S, Cohen J, Posner DC, Sangar R, Murray M, Wang X, Dochtermann DR, Devineni P, Shi Y, Nandi TN, Assimes TL, Brunette CA, Carroll RJ, Clifford R, Duvall S, Gelernter J, Hung A, Iyengar SK, Joseph J, Kember R, Kranzler H, Kripke CM, Levey D, Luoh SW, Merritt VC, Overstreet C, Deak JD, Grant SFA, Polimanti R, Roussos P, Shakt G, Sun YV, Tsao N, Venkatesh S, Voloudakis G, Justice A, Begoli E, Ramoni R, Tourassi G, Pyarajan S, Tsao P, O'Donnell CJ, Muralidhar S, Moser J, Casas JP, Bick AG, Zhou W, Cai T, Voight BF, Cho K, Gaziano JM, Madduri RK, Damrauer S, Liao KP
Science (New York, N.Y.) · 2024 · PMID 39024449 · open access

Questions about rs6948097

What is rs6948097?

rs6948097 is a single position in the genome, in or near the CDK6 gene. Published research associates it with atrial fibrillation (phecode 427.21). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs6948097 linked to?

On MyGeneLog this position is linked to Atrial Fibrillation. The research behind each link, and its sources, are set out on that condition page.

Does having rs6948097 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs6948097 come from?

GWAS Catalog, Science (New York, N.Y.) 2024, PMID:39024449. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Atrial fibrillation (PheCode 427.21) (rs6948097). MyGeneLog™. https://www.mygenelog.com/variants/rs6948097

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