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Primary biliary cholangitis

LOC102723649 · rs6933404

Where this position leads

What each result means

C/C Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Primary biliary cholangitis compared to the general population.

C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Primary biliary cholangitis.

T/T Published research associates this genotype with typical/baseline likelihood of Primary biliary cholangitis — no copies of the reported risk allele.

Source

International genome-wide meta-analysis identifies new primary biliary cirrhosis risk loci and targetable pathogenic pathways

Cordell HJ, Han Y, Mells GF, Li Y, Hirschfield GM, Greene CS, Xie G, Juran BD, Zhu D, Qian DC, Floyd JA, Morley KI

and 11 more — show all

Prati D, Lleo A, Cusi D, Gershwin ME, Anderson CA, Lazaridis KN, Invernizzi P, Seldin MF, Sandford RN, Amos CI, Siminovitch KA

Canadian-US PBC Consortium · Italian PBC Genetics Study Group · UK-PBC Consortium

Nature communications · 2015 · PMID 26394269 · open access

Questions about rs6933404

What is rs6933404?

rs6933404 is a single position in the genome, in or near the LOC102723649 gene. Published research associates it with primary biliary cholangitis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs6933404 linked to?

On MyGeneLog this position is linked to Primary Biliary Cholangitis. The research behind each link, and its sources, are set out on that condition page.

Does having rs6933404 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs6933404 come from?

GWAS Catalog, Nat Commun 2015, PMID:26394269. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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