Who was studied 24,087 European ancestry late-onset Alzheimer's disease cases, 47,793 European ancestry individuals with family history of Alzheimer's disease, 383,378 European ancestry controls.
The effect
Each copy of the T allele shifted the measure 6.49 z-unit lower; p = 8 × 10−11.
How common The T allele had a frequency of about 15% in the people studied.
Where it sits Chromosome 6, band 6p21.32 — between genes, 12.6 kb from HLA-DQA1.
What each result means
A/APublished research associates this genotype with typical/baseline likelihood of Alzheimer's disease or family history of Alzheimer's disease — no copies of the reported risk allele.
A/TPublished research associates this genotype (one copy of the reported risk allele) with an intermediate association with Alzheimer's disease or family history of Alzheimer's disease.
T/TPublished research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Alzheimer's disease or family history of Alzheimer's disease compared to the general population.
rs6931277 is a single position in the genome, in or near the HLA-DRB1 gene. Published research associates it with alzheimer's disease or family history of alzheimer's disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs6931277 linked to?
On MyGeneLog this position is linked to Alzheimer's Disease. The research behind each link, and its sources, are set out on that condition page.
Does having rs6931277 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs6931277 come from?
GWAS Catalog, Nat Genet 2019, PMID:30617256. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Alzheimer's disease or family history of Alzheimer's disease (rs6931277). MyGeneLog™. https://www.mygenelog.com/variants/rs6931277