near HLA-DQB1 · rs6905775
Where this position leads
Condition: Primary Sclerosing Cholangitis
What the study found
Who was studied at least 2,871 European ancestry cases, at least 12,019 European ancestry controls (MTAG boosted by autoimmune-related disease samples); replicated in at least 952 cases, 231,644 controls (MTAG boosted by autoimmune-related disease samples).
The effect Each copy of the A allele shifted the measure 0.199 lower (95% confidence interval 0.17-0.23); p = 4 × 10−39.
Where it sits Chromosome 6, band 6p21.32 — between genes, 1.2 kb from HLA-DQB1.
rs6905775 is a single position in the genome, in or near the near HLA-DQB1 gene. Published research associates it with primary sclerosing cholangitis (mtag). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Primary Sclerosing Cholangitis. The research behind each link, and its sources, are set out on that condition page.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Nature communications 2023, PMID:36828809. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Primary sclerosing cholangitis (MTAG) (rs6905775). MyGeneLog™. https://www.mygenelog.com/variants/rs6905775