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Primary biliary cholangitis

IL7R · rs6890853

Where this position leads

Condition: Primary Biliary Cholangitis

rs6890853 Condition: Primary Biliary Cholangitis Primary Biliary Cholangitis Condition rs6890853 rs6890853 IL7R

What the study found

Who was studied 487 Japanese ancestry cases, 476 Japanese ancestry controls; replicated in 787 Japanese ancestry cases, 615 Japanese ancestry controls.

The effect Each copy of the G allele carried 1.47 times the odds of Primary biliary cholangitis (95% confidence interval 1.28-1.69); p = 4 × 10−8.

Where it sits Chromosome 5, band 5p13.2 — between genes, 0.5 kb from IL7R.

What each result means

A/A No copy of the version the research linked to Primary biliary cholangitis. This is the starting point the study compared everyone against.
A/G One copy of the version the research linked to Primary biliary cholangitis. That is a smaller link than two copies.
G/G Two copies of the version the research linked to Primary biliary cholangitis. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source
Genome-wide association study identifies TNFSF15 and POU2AF1 as susceptibility loci for primary biliary cirrhosis in the Japanese population
Nakamura M, Nishida N, Kawashima M, Aiba Y, Tanaka A, Yasunami M, Nakamura H, Komori A, Nakamuta M, Zeniya M, Hashimoto E, Ohira H
and 68 more — show all
Yamamoto K, Onji M, Kaneko S, Honda M, Yamagiwa S, Nakao K, Ichida T, Takikawa H, Seike M, Umemura T, Ueno Y, Sakisaka S, Kikuchi K, Ebinuma H, Yamashiki N, Tamura S, Sugawara Y, Mori A, Yagi S, Shirabe K, Taketomi A, Arai K, Monoe K, Ichikawa T, Taniai M, Miyake Y, Kumagi T, Abe M, Yoshizawa K, Joshita S, Shimoda S, Honda K, Takahashi H, Hirano K, Takeyama Y, Harada K, Migita K, Ito M, Yatsuhashi H, Fukushima N, Ota H, Komatsu T, Saoshiro T, Ishida J, Kouno H, Kouno H, Yagura M, Kobayashi M, Muro T, Masaki N, Hirata K, Watanabe Y, Nakamura Y, Shimada M, Hirashima N, Komeda T, Sugi K, Koga M, Ario K, Takesaki E, Maehara Y, Uemoto S, Kokudo N, Tsubouchi H, Mizokami M, Nakanuma Y, Tokunaga K, Ishibashi H
American journal of human genetics · 2012 · PMID 23000144

Questions about rs6890853

What is rs6890853?

rs6890853 is a single position in the genome, in or near the IL7R gene. Published research associates it with primary biliary cholangitis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs6890853 linked to?

On MyGeneLog this position is linked to Primary Biliary Cholangitis. The research behind each link, and its sources, are set out on that condition page.

Does having rs6890853 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs6890853 come from?

GWAS Catalog, Am J Hum Genet 2012, PMID:23000144. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Primary biliary cholangitis (rs6890853). MyGeneLog™. https://www.mygenelog.com/variants/rs6890853

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