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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
Strength of the evidence
1 / 4
Its strongest genetic-study result is p = 10−19, with 2 associations in the GWAS Catalog.
How this is scored
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What the study found
Who was studied 448,010 European ancestry individuals.
The effect
Each copy of the A allele shifted the measure 0.02 lower (95% confidence interval 0.016-0.024); p = 3 × 10−19.
How common The A allele had a frequency of about 33% in the people studied.
Where it sits Chromosome 5, band 5q15 — in an intron of CAST.
What each result means
A/ATwo copies of the version the research linked to Estimated bone mineral density. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/COne copy of the version the research linked to Estimated bone mineral density. That is a smaller link than two copies.
C/CNo copy of the version the research linked to Estimated bone mineral density. This is the starting point the study compared everyone against.
Nature genetics · 2026 · PMID 42432248 · open access
Questions about rs6875585
What is rs6875585?
rs6875585 is a single position in the genome, in or near the CAST gene. Published research associates it with estimated bone mineral density. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs6875585 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs6875585 come from?
GWAS Catalog, Nature genetics 2026, PMID:42432248. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Estimated bone mineral density (rs6875585). MyGeneLog™. https://www.mygenelog.com/variants/rs6875585