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Male-pattern baldness

ZCCHC24 · rs6858

Where this position leads

Condition: Androgenetic Alopecia (Male Pattern Baldness)

rs6858 Condition: Androgenetic Alopecia (Male Pattern Baldness) Androgenetic Alopecia (Male Pattern… Condition rs6858 rs6858 ZCCHC24

What the study found

Who was studied 205,327 European ancestry males.

The effect Each copy of the T allele shifted the measure 0.0188 lower (95% confidence interval 0.013-0.025); p = 4 × 10−9.

How common The T allele had a frequency of about 41% in the people studied.

Where it sits Chromosome 10, band 10q22.3 — in the 3′ untranslated region of ZCCHC24.

What each result means

C/C Published research associates this genotype with typical/baseline likelihood of Male-pattern baldness — no copies of the reported risk allele.
C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Male-pattern baldness.
T/T Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Male-pattern baldness compared to the general population.
Source

Questions about rs6858

What is rs6858?

rs6858 is a single position in the genome, in or near the ZCCHC24 gene. Published research associates it with male-pattern baldness. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs6858 linked to?

On MyGeneLog this position is linked to Androgenetic Alopecia (Male Pattern Baldness). The research behind each link, and its sources, are set out on that condition page.

Does having rs6858 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs6858 come from?

GWAS Catalog, Nat Commun 2018, PMID:30573740. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Male-pattern baldness (rs6858). MyGeneLog™. https://www.mygenelog.com/variants/rs6858

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