Sensitive
Dementia and core Alzheimer's disease neuropathologic changes
PVRL2 · rs6857
Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What each result means
C/C
Published research associates this genotype with typical/baseline likelihood of Dementia and core Alzheimer's disease neuropathologic changes — no copies of the reported risk allele.
C/T
Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Dementia and core Alzheimer's disease neuropathologic changes.
T/T
Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Dementia and core Alzheimer's disease neuropathologic changes compared to the general population.
Source
Genome-wide association meta-analysis of neuropathologic features of Alzheimer's disease and related dementias
Beecham GW,
Hamilton K,
Naj AC,
Martin ER,
Huentelman M,
Myers AJ,
Corneveaux JJ,
Hardy J,
Vonsattel JP,
Younkin SG,
Bennett DA,
De Jager PL
and 24 more — show all
Larson EB,
Crane PK,
Kamboh MI,
Kofler JK,
Mash DC,
Duque L,
Gilbert JR,
Gwirtsman H,
Buxbaum JD,
Kramer P,
Dickson DW,
Farrer LA,
Frosch MP,
Ghetti B,
Haines JL,
Hyman BT,
Kukull WA,
Mayeux RP,
Pericak-Vance MA,
Schneider JA,
Trojanowski JQ,
Reiman EM,
Schellenberg GD,
Montine TJ
PLoS genetics · 2014 · PMID 25188341 · open access
What people read about alongside this
Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.
Questions about rs6857
What is rs6857?
rs6857 is a single position in the genome, in or near the PVRL2 gene. Published research associates it with dementia and core alzheimer's disease neuropathologic changes. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What do people read about alongside rs6857?
Subjects that appear in the title or abstract of the same papers as this rsID include blood sugar and insulin (2 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.
Does having rs6857 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs6857 come from?
GWAS Catalog, PLoS Genet 2014, PMID:25188341. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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