Granulocyte-macrophage colony-stimulating factor protein levels (SomaScan ID:4467-49)
SPARCL1 · rs6846462
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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 190 Shetland Isles origin ancestry individuals.
The effect
Each copy of the C allele shifted the measure 0.72 higher (95% confidence interval 0.56-0.88); p = 8 × 10−11.
Where it sits Chromosome 4, band 4q22.1 — in an intron of SPARCL1.
What each result means
C/CTwo copies of the version the research linked to Granulocyte-macrophage colony-stimulating factor protein levels (SomaScan ID:4467-49). That is the strongest link of the three results. A link in a study is not a diagnosis.
C/TOne copy of the version the research linked to Granulocyte-macrophage colony-stimulating factor protein levels (SomaScan ID:4467-49). That is a smaller link than two copies.
T/TNo copy of the version the research linked to Granulocyte-macrophage colony-stimulating factor protein levels (SomaScan ID:4467-49). This is the starting point the study compared everyone against.
Communications biology · 2025 · PMID 40883583 · open access
Questions about rs6846462
What is rs6846462?
rs6846462 is a single position in the genome, in or near the SPARCL1 gene. Published research associates it with granulocyte-macrophage colony-stimulating factor protein levels (somascan id:4467-49). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs6846462 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs6846462 come from?
GWAS Catalog, Communications biology 2025, PMID:40883583. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Granulocyte-macrophage colony-stimulating factor protein levels (SomaScan ID:4467-49) (rs6846462). MyGeneLog™. https://www.mygenelog.com/variants/rs6846462