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Who was studied 12,312 European ancestry cases, 389,344 European ancestry controls.
The effect
Each copy of the T allele carried 1.14 times the odds of Carpal tunnel syndrome (95% confidence interval 1.10–1.18); p = 6 × 10−12.
How common The T allele had a frequency of about 14% in the people studied.
Where it sits Chromosome 4, band 4p15.33 — between genes, 116.4 kb from HSP90AB2P.
What each result means
C/CNo copy of the version the research linked to Carpal tunnel syndrome. This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Carpal tunnel syndrome. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Carpal tunnel syndrome. That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature communications · 2019 · PMID 30833571 · open access
Questions about rs6843953
What is rs6843953?
rs6843953 is a single position in the genome, in or near the near HSP90AB2P gene. Published research associates it with carpal tunnel syndrome. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs6843953 linked to?
On MyGeneLog this position is linked to Carpal Tunnel Syndrome. The research behind each link, and its sources, are set out on that condition page.
Does having rs6843953 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs6843953 come from?
GWAS Catalog, Nature communications 2019, PMID:30833571. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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