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Intracranial aneurysm

EDNRA · rs6842241

Where this position leads

What the study found

Who was studied 1,383 Japanese ancestry cases, 5,484 Japanese ancestry controls; replicated in 1,048 Japanese ancestry cases, 7,212 Japanese ancestry controls.

The effect Each copy of the C allele carried 1.25 times the odds of Intracranial aneurysm (95% confidence interval 1.161-1.343); p = 1 × 10⁻⁸.

How common The C allele had a frequency of about 69% in the people studied.

Where it sits Chromosome 4, band 4q31.22 — between genes, 1.2 kb from EDNRA.

What each result means

A/A No copy of the version the research linked to Intracranial aneurysm. This is the starting point the study compared everyone against.

A/C One copy of the version the research linked to Intracranial aneurysm. That is a smaller link than two copies.

C/C Two copies of the version the research linked to Intracranial aneurysm. That is the strongest link of the three results. A link in a study is not a diagnosis.

Source

Genome-wide association study for intracranial aneurysm in the Japanese population identifies three candidate susceptible loci and a functional genetic variant at EDNRA

Low SK, Takahashi A, Cha PC, Zembutsu H, Kamatani N, Kubo M, Nakamura Y

Human molecular genetics · 2012 · PMID 22286173

What people read about alongside this

Blood sugar and insulin1

Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.

Questions about rs6842241

What is rs6842241?

rs6842241 is a single position in the genome, in or near the EDNRA gene. Published research associates it with intracranial aneurysm. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs6842241 linked to?

On MyGeneLog this position is linked to Intracranial Aneurysm. The research behind each link, and its sources, are set out on that condition page.

What do people read about alongside rs6842241?

Subjects that appear in the title or abstract of the same papers as this rsID include blood sugar and insulin (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.

Does having rs6842241 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs6842241 come from?

GWAS Catalog, Hum Mol Genet 2012, PMID:22286173. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Intracranial aneurysm (rs6842241). MyGeneLog™. https://www.mygenelog.com/variants/rs6842241

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