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Thyrotoxic periodic paralysis

TRIM2 · rs6827197

What the study found

Who was studied 306 Chinese ancestry male cases, 3,516 Chinese ancestry controls.

The effect The reported allele is T; the catalogue records no effect size ; p = 2 × 10−9.

How common The T allele had a frequency of about 3% in the people studied.

Where it sits Chromosome 4, band 4q31.3 — between genes, 36.8 kb from TRIM2.

What each result means

C/C No copy of the version the research linked to Thyrotoxic periodic paralysis. This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to Thyrotoxic periodic paralysis. That is a smaller link than two copies.
T/T Two copies of the version the research linked to Thyrotoxic periodic paralysis. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs6827197

What is rs6827197?

rs6827197 is a single position in the genome, in or near the TRIM2 gene. Published research associates it with thyrotoxic periodic paralysis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs6827197 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs6827197 come from?

GWAS Catalog, European journal of endocrinology 2020, PMID:33105104. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Thyrotoxic periodic paralysis (rs6827197). MyGeneLog™. https://www.mygenelog.com/variants/rs6827197

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