Sensitive

Type 2 diabetes

MAEA · rs6815464

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

Strength of the evidence

1 / 4

Its strongest genetic-study result is p = 10⁻²⁰, with 2 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10⁻⁵⁰. 2: ClinVar from one lab (1 star), or p ≤ 10⁻²⁰. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10⁻⁸). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 5,999 East Asian ancestry cases, 9,001 East Asian ancestry controls, 794 Malay ancestry cases, 1,240 Malay ancestry controls, 159 Filipino ancestry cases, 1,624 Filipino ancestry controls; replicated in 18,127 East Asian ancestry cases, 17,746 East Asian ancestry controls.

The effect Each copy of the C allele carried 1.13 times the odds of Type 2 diabetes (95% confidence interval 1.10-1.16); p = 2 × 10⁻²⁰.

How common The C allele had a frequency of about 58% in the people studied.

Where it sits Chromosome 4, band 4p16.3 — in an intron of MAEA.

How common each version is

CG

By ancestry gnomAD

East Asian

C 58.3% · G 41.8%

European (non-Finnish)

C 97.5% · G 2.5%

African / African American

C 87.2% · G 12.8%

South Asian

C 84.8% · G 15.3%

Admixed American (Latino)

C 78.5% · G 21.5%

Middle Eastern

C 95.9% · G 4.4%

Finnish

C 95.3% · G 4.6%

Ashkenazi Jewish

C 93.5% · G 6.5%

The share of all copies of this position that are each version. The ancestry rows are gnomAD's own groups (via Ensembl), as the survey defines them, not races.

What each result means

C/C Two copies of the version the research linked to Type 2 diabetes. That is the strongest link of the three results. A link in a study is not a diagnosis.

C/G One copy of the version the research linked to Type 2 diabetes. That is a smaller link than two copies.

G/G No copy of the version the research linked to Type 2 diabetes. This is the starting point the study compared everyone against.

DNA databases also record a third, rare version at this position, carried on fewer than one in a hundred copies of the DNA. The three results above cover the two common versions only.

Source

Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians

Cho YS, Chen CH, Hu C, Long J, Ong RT, Sim X, Takeuchi F, Wu Y, Go MJ, Yamauchi T, Chang YC, Kwak SH

and 56 more — show all

Ma RC, Yamamoto K, Adair LS, Aung T, Cai Q, Chang LC, Chen YT, Gao Y, Hu FB, Kim HL, Kim S, Kim YJ, Lee JJ, Lee NR, Li Y, Liu JJ, Lu W, Nakamura J, Nakashima E, Ng DP, Tay WT, Tsai FJ, Wong TY, Yokota M, Zheng W, Zheng W, Zhang R, Wang C, So WY, Ohnaka K, Ikegami H, Hara K, Cho YM, Cho NH, Chang TJ, Bao Y, Hedman ÅK, Morris AP, McCarthy MI, Takayanagi R, Park KS, Jia W, Chuang LM, Chuang LM, Chan JC, Maeda S, Kadowaki T, Lee JY, Wu JY, Teo YY, Tai ES, Shu XO, Mohlke KL, Kato N, Han BG, Seielstad M

DIAGRAM Consortium · MuTHER Consortium

Nature genetics · 2011 · PMID 22158537

Quoting this page

Licensed CC BY-NC 4.0: free to read, share and adapt for non-commercial use, naming MyGeneLog™ and linking the exact page. Commercial use, including training or serving a commercial AI system, needs a licence — https://www.mygenelog.com/license

Type 2 diabetes (rs6815464). MyGeneLog™. https://www.mygenelog.com/variants/rs6815464

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